Part:BBa_K4482010

NT3

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor). Although the vast majority of neurons in the mammalian brain are formed prenatally, parts of the adult brain retain the ability to grow new neurons from neural stem cells; a process known as neurogenesis. Neurotrophins are chemicals that help to stimulate and control neurogenesis. NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB). NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB. (Source: wikipedia).

Sequence and Features

Assembly Compatibility:

• 10
  INCOMPATIBLE WITH RFC[10]

  Illegal EcoRI site found at 585
  Illegal EcoRI site found at 678
  Illegal XbaI site found at 439
  Illegal SpeI site found at 694
  Illegal PstI site found at 22
  
• 12
  INCOMPATIBLE WITH RFC[12]

  Illegal EcoRI site found at 585
  Illegal EcoRI site found at 678
  Illegal SpeI site found at 694
  Illegal PstI site found at 22
  
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal EcoRI site found at 585
  Illegal EcoRI site found at 678
  Illegal BamHI site found at 83
  
• 23
  INCOMPATIBLE WITH RFC[23]

  Illegal EcoRI site found at 585
  Illegal EcoRI site found at 678
  Illegal XbaI site found at 439
  Illegal SpeI site found at 694
  Illegal PstI site found at 22
  
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal EcoRI site found at 585
  Illegal EcoRI site found at 678
  Illegal XbaI site found at 439
  Illegal SpeI site found at 694
  Illegal PstI site found at 22
  
• 1000
  COMPATIBLE WITH RFC[1000]